Linearity/non-linearity . Ann Intern Med. Like all medicines, sertraline can cause side effects in some people, but many people have no side effects or only minor ones. Sometimes people respond better to one antidepressant than another. Take sertraline once a day. Sertraline-related night sweats. Only a small amount (<0.2%) of unchanged sertraline is excreted in the urine. Babbott SF, Pearson VE. Do not drive or use tools or machinery if you're feeling sleepy. The phase IV clinical study is created by eHealthMe based on reports of 114,019 people who have side effects when taking Zoloft from the FDA, and is updated regularly. You can take sertraline with or without food. It's still important to get help from a GP if you need it. They're usually mild and go away after a couple of weeks. A few people may get sexual side effects, such as problems getting an erection or a lower sex drive. Selective serotonin reuptake inhibitors (SSRIs) are a class of drug commonly used to treat depression.The drugs help normalize brain function in people with certain mood disorders by increasing the amount of serotonin in the brain. Next review due: 12 December 2021. Drug safety fears have emerged after a common anti-depressant was linked to two deaths. Ask your pharmacist to recommend a painkiller. Menu Book an appointment with your doctor if you get: In rare cases, it's possible to have a serious allergic reaction (anaphylaxis) to sertraline. Is sertraline better than other antidepressants? You may notice that you sleep better and get on with people more easily because you're less anxious. It happens rarely (in less than 1 in 100 people), but some people may have serious side effects when taking sertraline. The most common reasons for night sweats are: Sometimes the cause of night sweats is unknown. It's not known whether this reduces male fertility. As men age and get past 40, testosterone levels drop as much as one percent per year. You'll be regularly checked for this. have had an allergic reaction to sertraline or any other medicines in the past, have a heart problem – sertraline can speed up or change your heartbeat, have ever taken any other medicines for depression – some rarely used antidepressants can interfere with sertraline to cause very high blood pressure, even when they have been stopped for a few weeks, are trying to become pregnant, already pregnant or breastfeeding, chest pain or pressure, or shortness of breath, painful erections that last longer than 4 hours – this may happen even when you're not having sex, any bleeding that's very bad or you cannot stop, such as cuts or nosebleeds that do not stop within 10 minutes, headaches, trouble focusing, memory problems, not thinking clearly, weakness, seizures, or losing your balance – these can be signs of low sodium levels, thoughts about harming yourself or ending your life, fits, feelings of euphoria, excessive enthusiasm or excitement, or a feeling of restlessness that means you cannot sit or stand still, yellow skin or the whites of your eyes turn yellow – this can be a sign of liver problems, vomiting blood or dark vomit, coughing up blood, blood in your pee, black or red poo – these can be signs of bleeding from the gut, bleeding from the gums or bruises that appear without a reason or that get bigger, changes in your periods, such as heavy bleeding, spotting or bleeding between periods, weight gain or weight loss without trying, you get a skin rash that may include itchy, red, swollen, blistered or peeling skin, your mouth, face, lips, tongue or throat start swelling, any medicines that affect your heartbeat – sertraline can speed up or change your heartbeat, any other medicines for depression – some antidepressants can interfere with sertraline to cause very high blood pressure even when they have been stopped, numbness or tingling in the hands or feet, men getting painful erections and problems with getting an erection and ejaculating, women having some vaginal bleeding and not reaching orgasm the same way as before, talking therapy (such as cognitive behavioural therapy), whether you have had any previous periods of depression, how likely you are to stick with your treatment, stimulants like MDMA (ecstasy) or cocaine, novel psychoactive substances (which used to be known as legal highs) like mephedrone. 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